Endocrine pathway controlling secretions

This website provides navigation menus, so you always know where you are when searching for the information you need. Articleinput.com was founded this year (2009) with the sole purpose to bring you at ease while solving a problem.Now I am going to write about an article regarding Endocrine pathway controlling secretions.Growth Hormone-Releasing Peptides (GHRP) were discovered by C.Y. Bowers and his group in 1976. Experimenting with the metenkephalin molecule they identified through theoretic low-energy conformational calculations, computer modelling, and structural modification a series of small peptides that are able to stimulate GH secretion.At that time these compounds were not considered to be endogenous releasing peptides.In the early eighties the first highly potent GHRP-6 (hexapeptide) was developed. This compound increases GH secretion acting both at the hypothalamic and pituitary level. Subsequent studies into the nature and activity of GHRP-6 and its follow-up compounds has led to a number of findings which are relevant to clinical practice. In retrospect it is interesting to note that GHRPs were constructed well before the isolation and characterization of Growth Hormone Releasing Hormone (GHRH) in 1982. For many years it was thought that the pulsatile secretion of GH by the pituitary somatotrophs was controlled by only two antagonistic hypothalamic peptides: somatostatin which inhibits GH release and GHRH which stimulates GH release. Both peptides had been purified and well characterized, while their specific receptors have been cloned.Both GHRH and somatostatin receptors belong to the family of seven transmembrane receptors coupled to a heterotrimeric GTP-binding protein. The somatostatin receptor is coupled to a Gi protein and its activation inhibits adenylate cyclase. On the other hand, the GHRH receptor is coupled to a Gs protein and its activation stimulates adenylate cyclase activity leading to increased intracellular cycUc AMP levels. The discovery of the GHRPs has led to the hypothesis of a third endocrine pathway controlling GH secretion, and indeed human GHRP receptors eventually have been cloned in the anterior pituitary and hypothalamus. GHRP pituitary action is mediated via a phosphoinositol-protein kinase-C intracellular pathway,.You can also visit hormonal infusions in this site.

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